The Ion Torrent Ion S5 semiconductor sequencer by Thermo Fisher Scientific delivers fast and efficient next-generation sequencing with semiconductor technology. This compact instrument provides scalable throughput options suitable for diverse sequencing applications in research and clinical labs. Featuring an intuitive touchscreen interface and integrated reagent storage, the S5 streamlines workflow for user convenience. Reliable base calling is achieved through direct detection using semiconductor sensors without optics or cameras. The instrument includes advanced software version 5.12.3 for robust data processing and instrument control. Its modular design supports flexible configuration and ease of maintenance, making it ideal for targeted sequencing, gene expression, and small genome analysis.