Why you should stick with your current MiSeq – and how Surplus Solutions can support you.
Kevin Richardson
Kevin Richardson
1. Legacy Provenance & Workflow Familiarity
For many labs, the MiSeq has been a workhorse—widely validated, with known performance across dozens of applications. As of 2025, it remains one of the most cited benchtop sequencers, trusted by over 10,000 customers and referenced in more than 160,000 peer-reviewed publications. Keeping your current system avoids the disruption of retraining, validating new protocols, or re-optimizing workflows.
2. Avoid the Burden of Revalidation
Switching to a new sequencer isn’t just plug-and-play. In regulated or clinical environments, adopting a new or upgraded sequencer means revalidating assays, workflows, and quality control procedures to ensure compliance. This adds time, labor, and cost—while potentially delaying projects. By contrast, keeping the MiSeq avoids this hurdle, since your current assays are already validated and producing reliable data.
3. Sufficient for Many Applications
If your needs primarily involve targeted gene panels, amplicon sequencing, small genomes, or regular QC, the MiSeq continues to deliver reliable results—accurate and cost-effective. It’s a compact instrument already integrated into many lab schedules, and unless your throughput needs have dramatically increased, it may continue to meet demand.
4. Cost-Effective Maintenance
Surplus Solutions offers expert repairs and service contracts for legacy sequencers—including older, even OEM-unsupported systems. With over two decades of experience, the Surplus Solutions team can keep your MiSeq running reliably, minimizing downtime and maximizing ROI.
5. Budget-Friendly Compared to i100 Prices
A new sequencer such as the MiSeq i100 series comes with a hefty price tag: list prices hover around $49,000 for the base model and $109,000 for the higher-throughput i100 Plus. Staying with your current sequencer avoids that capital outlay and may be especially compelling for labs operating under constrained budgets.
6. Gradual Transition Strategy
Retaining the MiSeq while planning a future upgrade allows for a smoother transition—one that avoids workflow disruptions and spreads budget impact over time.
Choose Surplus Solutions as your partner to keep your original MiSeqs in top condition
If your lab’s current MiSeq is meeting your needs in terms of throughput, result quality, and scheduling, there’s a compelling case to keep using it—particularly when you can rely on Surplus Solutions for cost-effective servicing and consumables. The MiSeq i100 series does offer some advantages in speed, simplicity, and sustainability—but unless those benefits align with critical lab needs, sticking with what’s proven may be the smarter, and far less costly choice.
Want to know more? Submit this form and one of our service team members will be in contact with you!
